To compute the probability of subsystem B being in a specific state, one must sum the probabilities of outcomes where subsystem B is in that state, while considering the overall system state. For example, when measuring a two-qubit system, the probability of measuring the second qubit in state |0⟩ involves projecting the combined state onto the subspace corresponding to |0⟩ and calculating the norm of the resulting state. It's important to note that if the subsystems are entangled, the measurement of one subsystem can affect the state of the other, requiring a different approach. However, if the subsystems are separate, operators on one subsystem commute with the state of the other, simplifying the calculation. Understanding these principles is crucial for accurately determining probabilities in quantum systems.