22 AWG wire can technically handle up to 7A, but practical usage depends on factors like cooling and environment, especially in sealed boxes with heat-generating components. If the design involves high current and potential voltage drops, using larger wire or multiple 22 AWG wires may be necessary to ensure safety and performance. The discussion highlights the importance of avoiding soldering power wires directly to prototype boards to prevent damage; using pins or headers is recommended for easier connections. Additionally, decoupling capacitors are crucial for maintaining stable voltage in high-power applications. Ultimately, while 22 AWG can work, careful consideration of the setup and conditions is essential for reliable operation.