Filling a 4-5 foot piece of surgical hose with helium is unlikely to result in it standing vertically due to the thick walls of the hose, which may offset the buoyancy of the helium. To determine if it would float or stand, one can calculate the weight of the hose filled with helium compared to the weight of the same volume of air. If the hose weighs less than the helium-filled volume, it will float; if it weighs slightly more, it may stand upright; if it weighs considerably more, it will remain on the ground. The discussion highlights that unlike a balloon, which can regulate its position with a string, the hose lacks this feature, making it less likely to achieve a stable vertical position.