To enable mathematical typesetting on a website, install TeX software like MikTeX and a LaTeX editor such as LED. Additionally, ImageMagick is required for displaying images, along with Ghostscript and GSView. Proper configuration of the web server is essential, including specifying the paths to the LaTeX and ImageMagick executables. For MediaWiki installations, specific settings in the LocalSettings.php file are necessary, such as enabling TeX and defining commands for ImageMagick and LaTeX. It's important to consult the documentation for the software being used, as configurations may vary based on the server environment.