Can microbes combat neurodegeneration? - Apparently YES

  • Thread starter Thread starter Tom.G
  • Start date Start date
AI Thread Summary
Research indicates that the gut microbiome may significantly influence ALS symptoms, particularly observed in mice studies. Findings show that gut bacteria produce nicotinamide, which notably enhances motor abilities and spinal cord gene expression in these mice. Preliminary evidence suggests similar effects could be present in humans, as sequencing the gut microbiome of ALS patients compared to healthy family members reveals potential links. This emerging area of study highlights the gut microbiome's potential role in ALS treatment and warrants further investigation to explore its implications for patient care.
Tom.G
Science Advisor
Gold Member
Messages
5,661
Reaction score
4,504
At least for ALS symptoms in mice; and some suspicions in humans based on sequencing the gut microbiome of patients vs. healthy family members in the same household.

They found that the gut bugs produced nicotinamide which "...substantially improved motor abilities and spinal cord gene expression in [the] mice."
https://science.sciencemag.org/content/373/6551/172.long

and other articles at
https://pubmed.ncbi.nlm.nih.gov/34244406/
 
  • Like
  • Informative
Likes Aanta, Not anonymous and Lnewqban
Biology news on Phys.org
That's really interesting! It seems like the gut microbiome could have a huge impact on ALS symptoms, not just in mice but potentially in humans as well. I'm looking forward to more research on this topic, and seeing if it can make a difference in the lives of those who suffer from ALS.
 
https://www.nhs.uk/mental-health/conditions/body-dysmorphia/ Most people have some mild apprehension about their body, such as one thinks their nose is too big, hair too straight or curvy. At the extreme, cases such as this, are difficult to completely understand. https://www.msn.com/en-ca/health/other/why-would-someone-want-to-amputate-healthy-limbs/ar-AA1MrQK7?ocid=msedgntp&cvid=68ce4014b1fe4953b0b4bd22ef471ab9&ei=78 they feel like they're an amputee in the body of a regular person "For...
Thread 'Did they discover another descendant of homo erectus?'
The study provides critical new insights into the African Humid Period, a time between 14,500 and 5,000 years ago when the Sahara desert was a green savanna, rich in water bodies that facilitated human habitation and the spread of pastoralism. Later aridification turned this region into the world's largest desert. Due to the extreme aridity of the region today, DNA preservation is poor, making this pioneering ancient DNA study all the more significant. Genomic analyses reveal that the...
Popular article referring to the BA.2 variant: Popular article: (many words, little data) https://www.cnn.com/2022/02/17/health/ba-2-covid-severity/index.html Preprint article referring to the BA.2 variant: Preprint article: (At 52 pages, too many words!) https://www.biorxiv.org/content/10.1101/2022.02.14.480335v1.full.pdf [edited 1hr. after posting: Added preprint Abstract] Cheers, Tom

Similar threads

Replies
1
Views
2K
Back
Top