Can microbes combat neurodegeneration? - Apparently YES

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Research indicates that the gut microbiome may significantly influence ALS symptoms, particularly observed in mice studies. Findings show that gut bacteria produce nicotinamide, which notably enhances motor abilities and spinal cord gene expression in these mice. Preliminary evidence suggests similar effects could be present in humans, as sequencing the gut microbiome of ALS patients compared to healthy family members reveals potential links. This emerging area of study highlights the gut microbiome's potential role in ALS treatment and warrants further investigation to explore its implications for patient care.
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At least for ALS symptoms in mice; and some suspicions in humans based on sequencing the gut microbiome of patients vs. healthy family members in the same household.

They found that the gut bugs produced nicotinamide which "...substantially improved motor abilities and spinal cord gene expression in [the] mice."
https://science.sciencemag.org/content/373/6551/172.long

and other articles at
https://pubmed.ncbi.nlm.nih.gov/34244406/
 
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That's really interesting! It seems like the gut microbiome could have a huge impact on ALS symptoms, not just in mice but potentially in humans as well. I'm looking forward to more research on this topic, and seeing if it can make a difference in the lives of those who suffer from ALS.
 

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