Can microbes combat neurodegeneration? - Apparently YES

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SUMMARY

The discussion centers on the potential of gut microbiomes to combat neurodegeneration, specifically in the context of Amyotrophic Lateral Sclerosis (ALS). Research indicates that gut microbes in mice produce nicotinamide, which significantly enhances motor abilities and spinal cord gene expression. Preliminary findings suggest that similar effects may be observed in humans, based on gut microbiome sequencing of ALS patients compared to healthy family members. This emerging evidence highlights the gut-brain connection as a promising area for ALS treatment research.

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  • Understanding of gut microbiome functions
  • Knowledge of neurodegenerative diseases, particularly ALS
  • Familiarity with nicotinamide and its biological roles
  • Basic concepts of gene expression and its implications in motor functions
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  • Research the role of gut microbiomes in neurodegenerative diseases
  • Explore the mechanisms of nicotinamide in neurological health
  • Investigate current studies on ALS and gut microbiome interactions
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Researchers in neurobiology, healthcare professionals focusing on ALS treatment, and anyone interested in the intersection of microbiome science and neurodegenerative disease management.

Tom.G
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At least for ALS symptoms in mice; and some suspicions in humans based on sequencing the gut microbiome of patients vs. healthy family members in the same household.

They found that the gut bugs produced nicotinamide which "...substantially improved motor abilities and spinal cord gene expression in [the] mice."
https://science.sciencemag.org/content/373/6551/172.long

and other articles at
https://pubmed.ncbi.nlm.nih.gov/34244406/
 
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That's really interesting! It seems like the gut microbiome could have a huge impact on ALS symptoms, not just in mice but potentially in humans as well. I'm looking forward to more research on this topic, and seeing if it can make a difference in the lives of those who suffer from ALS.
 

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