Can Sirtuin Activators Really Extend Human Longevity Safely?

AI Thread Summary
Sirtuins are enzymes that play a crucial role in repairing telomeres, which deteriorate and contribute to aging. These enzymes are typically activated by stressors like calorie restriction or low insulin levels, but can also be stimulated by certain chemicals, including resveratrol, a compound found in red wine. The discussion raises questions about the feasibility of taking high concentrations of resveratrol daily to enhance sirtuin activity, potentially leading to significant lifespan extension and reduced risks of cancer and heart disease. Concerns about the safety and efficacy of such high doses, along with ethical considerations from regulatory bodies like the FDA, contribute to the controversy surrounding the use of resveratrol and sirtuins in anti-aging therapies. The debate highlights the complexity of aging mechanisms and the need for further research to clarify the roles of sirtuins and resveratrol in promoting longevity.
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Sirtuins are enzymes which repair telemeres that deteriorate to cause aging. They are normally released in response to stress such as calorie restriction or low insulin levels, but sir2 can be stimulated by certain chemicals. Why is it unfeasible to take molecules like resveratrol (found in red wine) daily in high concentration in order to release these enzymes and effectively live 40% longer with a lower risk of cancer and heart disease? Are there genuine concerns or is the FDA just ethically hesitant to approve such drugs?
 
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