Can the Nernst Equation Determine Missing Sodium Concentrations?

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The discussion centers on using the Nernst Equation to determine missing sodium concentrations in a study involving ion concentrations in extracellular fluid (ECF) and intracellular fluid (ICF). A retired neurophysiologist reported various ion concentrations but lacked instruments to measure sodium levels. Participants suggest using the Nernst Equation, Em = 58/z * log(xo/xi), to calculate the equilibrium potential for chloride ions and then relate it to potassium levels. The challenge lies in connecting these calculations to derive the sodium concentrations accurately. Overall, the thread seeks clarity on applying the Nernst Equation in this context to solve for sodium.
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A rather tame ltxnsp was recently found on Easter Island by a retired neurophysiologist. He reported the following measurements of ECF and ICF concentrations (in millimoles):
ICF ECF
Pr+ 0 150
Na+ ? ?
K+ 10 100
Cl- 109 250
HCO3- 1 10


so this is the question: He lacked the proper instruments for determining Na+ concentrations, but was rather certain that no other major ions were present in the ECF and ICF. Can you calculate either concentration for him?

I think we use the Nernst eqn in this case to figure it out which is Em= 58/ z * log (xo/xi). correct me if I'm wrong. So Na and Cl is transported via the symporter so only charges are opposite. therefore we find the Em of Cl-? Then after that we find what's K? But then I don't get how to use those to tie it to find Na. I'm confusing myself here. Can someone help me out.
 
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Try using net neutrality of the bulk.
 
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