QM is a theory about observations, so, of course you can do it. Observation is a primitive of the theory.
To get a better understnding of exactly what a state is check out post 137:
https://www.physicsforums.com/threads/the-born-rule-in-many-worlds.763139/page-7
The key fundamental axiom is:
An observation/measurement with possible outcomes i = 1, 2, 3 ... is described by a POVM Ei such that the probability of outcome i is determined by Ei, and only by Ei, in particular it does not depend on what POVM it is part of.
Note that an observation is an undefined primitive of the theory, like particle is an undefined primitive of classical mechanics, or point is and undefined primitive of Euclidean geometry etc etc. We have an intuitive idea what they mean and as the theory is developed you get a better idea, but that is typical of physical theories. Mathematicians work to a higher standard and if you go and study a book like Geometry Of Quantum theory by Varadarjan you will find exact mathematical definitions of such things - but how you apply them - that's another matter. As Einstein said - 'As far as the laws of mathematics refer to reality, they are not certain; and as far as they are certain, they do not refer to reality.' Also that approach is what is euphemistically referred to by mathematicians as non-trivial - meaning its HARD.
Now from that axiom alone we have, via Gleason, Born's Rule. The state is simply a mathematical requirement following from that axiom. It's not real, telling us something is smeared our or anything like that. It, just like probabilities, tells us about the expected value of observations.
What decoherence does is refine the concept of observation. You get a mixed state in the basis of what you are observing ie the state is Σpi |bi><bi| and the observable is Σyi |bi><bi|. Now let's suppose its a proper mixed state then the system is actually, prior to observation, in some state |bi><bi| with probability pi. When you observe it with the observable O = Σyi |bi><bi| the yi you get tells you what |bi><bi| there is. Its not changed by the observation (if its a filtering type observation) and in that sense it can be considered an objective property of the system. Everything is much more classical and common-sense. It reveals something there beforehand - no problem of outcomes - its there before you observe it. But it isn't a proper mixed state - its an improper state - it's observationally indistinguishable from a proper one - but it's not the same. This is the problem of outcomes - why do we get an outcome. The fundamental axiom says we will - but why.
That said I think far too many people get caught up with this. Its simply the fundamental axiom of QM - that observations exist and have outcomes is a primitive of the axiom and the theory. Its no different to other primitives like point particle, point, event, and a myriad of other primitives in physics. Its simply part of the scientific method - every theory has assumed primitives.
Thanks
Bill