The last reaction in the CNO-I cycle involves the fusion of nitrogen-15 and hydrogen to produce carbon-12 and helium, rather than oxygen-16, due to branching ratios. While oxygen-16 can theoretically be produced, it occurs less frequently because the necessary energy states are not as favorable as those for carbon-12. The CNO cycle relies on carbon, nitrogen, and oxygen as catalysts, with the most significant reactions being those that produce alpha particles from protons. The rarity of multiple particles fusing into one is attributed to energy conservation constraints, requiring precise energy levels for successful reactions. Overall, the processes with higher branching ratios dominate, leading to the observed outcomes in stellar nucleosynthesis.