What are you trying to measure? For most measurements the mismatch shouldn't be too much of a problem; most of the the reflected power will be absorbed inside the VNA to standing waves etc shouldn't be too much of a problem.
The "proper" way of doing this is to set the characteristic impedance to 75 Ohm in the calibration menus of the VNA and then use a 75 Ohm calibration kit. However, these are rare and quite expensive.
You could try de-embedding the DUT using a pad, but that is quite tricky; at least if you need an accurate measurement.
Also, be careful when you connect your device to the VNA; 75 Ohm connectors DO NOT FIT on 50 ohm systems; you MUST use an adapter (or a minimum loss pad or something similar) or you WILL destroy the connectors on the VNA.