Copies of the SIR6 gene help reverse aging

AI Thread Summary
The discussion centers on the potential implications of the SIR6 gene in aging, specifically whether increasing its copies could reverse aging effects, given that its deletion may accelerate aging. Concerns are raised about the safety of having more copies of the SIR6 gene, emphasizing the need for experimental evidence to substantiate any claims regarding its role in aging. The mitochondrial theory of aging is also mentioned, prompting questions about methods to counteract mtDNA decay. Participants highlight the importance of providing context and references to support claims, indicating that more information is needed to facilitate a productive discussion on the SIR6 gene's implications. A reference to a relevant scientific article is provided to guide further inquiry.
bioquest
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So would more copies of the SIR6 gene help reverse aging or anything like that if it's possible that deletion of the SIR6 gene speeds up aging a large amount? How dangerous would it be to have more copies of the SIR6 gene?

If the mitochondrial theory of aging is correct, is there a way to counteract the potential effects of the decay in mtDNA? What ways would there be to do that?
 
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bioquest said:
So would more copies of the SIR6 gene help reverse aging or anything like that if it's possible that deletion of the SIR6 gene speeds up aging a large amount? How dangerous would it be to have more copies of the SIR6 gene?

This is an experimental question, no one can answer it unless that experiment has been done and someone here happens to know about it. Though, I suspect there must be some reason to think this gene would do something like that, otherwise you would not have mentioned it. Perhaps, if you provided us with some more context for your question (like where you heard of this gene) people might be able to be more helpful.
 
FWIW Sir6 seems to be a clonal cell line and not a gene.
You will need to post a reference to what you are referring to.

EDIT: Here is a reference to SIR6
J. Biol. Chem., Vol. 279, Issue 3, 2053-2062, January 16, 2004

http://www.jbc.org/cgi/content/full/279/3/2053#FIG6
 
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