Could Mini-Brains Grown in a Lab Be the Next Big Breakthrough in Neuroscience?

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The discussion centers on the development of a three-dimensional organoid culture system, known as cerebral organoids, derived from human pluripotent stem cells. These organoids replicate various interdependent brain regions, including a cerebral cortex that contains progenitor populations responsible for organizing and producing mature cortical neuron subtypes. The cerebral organoids effectively mirror key aspects of human cortical development, showcasing characteristic organization of progenitor zones and a significant presence of outer radial glial stem cells. The innovative research highlights the potential for studying brain development and related disorders using these organoids.
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Here we have developed a human pluripotent stem cell-derived three-dimensional organoid culture system, termed cerebral organoids, that develop various discrete, although interdependent, brain regions. These include a cerebral cortex containing progenitor populations that organize and produce mature cortical neuron subtypes. Furthermore, cerebral organoids are shown to recapitulate features of human cortical development, namely characteristic progenitor zone organization with abundant outer radial glial stem cells.

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12517.html
 
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