Deceptive curcumin offers cautionary tale for chemists

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The discussion centers around a cautionary article regarding curcumin, highlighting its misleading properties for drug development. It points out that chemists have long warned about the deceptive nature of curcumin and similar compounds, suggesting that many natural products may also possess undesirable chemical characteristics yet still hold significant therapeutic value. The conversation raises questions about the prevalence of such "ugly" natural products in the pharmaceutical landscape and their potential applications in therapy.
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http://www.nature.com/news/deceptive-curcumin-offers-cautionary-tale-for-chemists-1.21269

Funny they should say the 'cautionary tale' is 'for chemists', given that the article itself then says:
'For years, chemists have urged caution about curcumin and other compounds that can mislead naive drug hunters.'

More in general, I wonder how many natural products are chemically just as ugly as curcumin, but nevertheless do have important applications in therapy.
 
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lavoisier said:
More in general, I wonder how many natural products are chemically just as ugly as curcumin, but nevertheless do have important applications in therapy.
How many "natural products" are there at least as ugly as curcumin?
 
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