Diabetes & Glucagon: Why Do Levels Rise?

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Glucagon levels rise during diabetes primarily due to the insufficient insulin production or action, leading to an imbalance in the insulin:glucagon ratio. In untreated diabetes, especially type 1, the lack of insulin results in unregulated glucagon secretion from the alpha cells of the pancreas. This rise in glucagon contributes to increased glucose production by the liver, exacerbating hyperglycemia. The discussion highlights the importance of understanding this hormonal interplay, emphasizing that the metabolic disturbances in diabetes can be attributed to the altered insulin:glucagon dynamics rather than solely elevated glucagon levels. Resources like Wikipedia and educational websites are recommended for further clarification on the mechanisms involved.
goingmad
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Why is it the case that glucagon levels actually rise during diabetes? This seems to be what's implied everywhere I look. What causes the rise? Is it more accurate to say that all the metabolic things that start happening with untreated diabetes is because of the drop in the insulin:glucagon ratio in general? Is it even the case that glucagon levels rise?
I'm so confused about this!
Thanks,
 
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Try Wiki. They have a pretty good summary.
 
This site may also help you understand how it works.

http://www.deo.ucsf.edu/type1/understanding-diabetes/how-the-body-processes-sugar/blood-sugar-and-other-hormones.html
 
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