Diabetic Neuropathy: Pathophysiology & Statistics

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The discussion centers on the pathophysiological mechanisms underlying the development of neuropathy in diabetes. A significant focus is on the Polyol Pathway, which is frequently cited as a potential cause but remains controversial and lacks conclusive evidence regarding its role in damaging microvasculature. Participants express frustration over the scarcity of credible theories and comprehensive explanations from modern science regarding diabetic neuropathy. Additionally, oxidative stress on neuronal components is highlighted as a critical factor, with biochemical pathways related to this stress being referenced in scientific literature. Overall, the conversation emphasizes the need for further research to clarify the mechanisms linking diabetes to neuropathy.
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What is the pathophysiological basis for development of neuropathy in diabetes. Or is it just statistics that we find neuropathy in many diabetic patients'.
 
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Thanks for your reply. I too have searched Google and got nothing better. Most of the articles return 'Polyol Pathway' as the probable cause for neuropathy due to diabetes. But mostly they are skeptical of it. Wikipedia on "Polyol Pathway" states, ... "It has not been conclusively determined that activating the polyol pathway damages microvasculature"...

Why modern science is unable to produce a credible theory for developing neuropathy due to diabetes?
 

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