Roughly speaking, all smooth Riemann surfaces of genus 2 are double covers of the (complex) projective "line" P^1, branched at 6 distinct points. If they are complex holomorphically isomorphic, then it seems there must be an isomorphism of P^1, i.e. a Mobius transformation, taking the branch points of one to those of another. But the Mobius group has only 3 complex parameters, so we could produce two non isomorphic Riemann surfaces of genus 2, by letting them both have branch points at {0,1,infinity} as well as at three more points, such that the two choices of the extra three points are not carried to one another by the finite group of Mobius transforms that permute the three points...Hmmmm, I guess it is not quite that simple.
I guess I would have to identify the finite group that permutes the given 6 points, including {0,1,infinity} and then choose another point not in any of those orbits.OK here is a link (below) to a paper distinguishing surfaces of genus 2 by their different automorphism groups. the point is that all such surfaces have equations of form y^2 = f(x), where f has degree 5 (or 6 if you wish), according to whether or not you put a branch point (the zeroes of f) at infinity. All such surfaces admit the automorphism (x,y)-->(x,-y), and some have more. The quotient by that distinguished automorphism is P^1, and is called therefore a genus zero involution. All other involutions have quotient an elliptic curve, (and 2 branch, i.e. fixed points) and are called genus one involutions.
It follows that such special genus 2 curves are also branched double covers of elliptic curves, with 2 branch points, so you might construct examples of distinct special genus 2 curves by looking at special elliptic curves with known automorphisms, and choosing the branch points to be zero and one other. The possible automorphisms of elliptic curves (with a chosen fixed point, hence group isomorphisms) are well known, and the special cases correspond to certain special symmetric plane lattices, such as repetitions of a square or a hexagon.
Anyway, the following genus 2 curves seem to have distinct automorphism groups, hence are not isomorphic:
y^2 = X^5 - X, y^2 = X^6-X, y^2 = X^6-1.
see this paper, esp.pages 9,10,17?
https://arxiv.org/pdf/math/0107142.pdfsomewhat more in the spirit of zinq's discussion, one could view a genus 2 curve as a quotient of the disc, or upper half plane, by a hyperbolic group, and describe two inequivalent hyperbolic tessellations of the disc, by distinct hyperbolic groups.