Medical Difference Between Amphetamine & Methamphetamine: Effects Explained

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Amphetamine and methamphetamine are chemically similar, both functioning as central nervous system stimulants that produce euphoria and affect neurotransmitter modulation. The primary difference lies in their chemical structure, specifically the presence of a methyl group in methamphetamine. While both drugs share similar physical and psychological effects, methamphetamine is often associated with more severe side effects, including a higher potential for addiction and psychosis. The prevalence of abuse varies by region, influenced by sociopolitical, geographic, and economic factors. In some areas, recreational use of amphetamines is more common, while methamphetamine, particularly in its crystal form, is less frequently encountered. The discussion highlights that perceptions of drug abuse are shaped by cultural context and social circles.
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what's the difference...

......between amphetamine and methamphetamine, effect wise?
 
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yeah, well. they have the pretty much the same physical and psychological effects. still, i haven't heard of 'amphetamine' abuse. so i was wondering what makes methamphetamine different from amphemphetamine.
 


Different in what sense? Whether or not you have heard of abuse depends on what country you live in and what your social circle is. Also the definition of "abuse", recreational use of amphetamine is far more common in the United Kingdom (MDMA is very popular whereas crystal meth is more or less unheard of).
 


ryan_m_b said:
Different in what sense? Whether or not you have heard of abuse depends on what country you live in and what your social circle is. Also the definition of "abuse", recreational use of amphetamine is far more common in the United Kingdom (MDMA is very popular whereas crystal meth is more or less unheard of).

MDMA is a methamphetamine just like crystal meth. The difference between an amphetamine and a methamphetamine is a methyl group on the amine moiety.

As far as the difference in effects go, they work very similarly (CNS stimulation, euphoria, modulation of neurotransmitters etc). They are also metabolized in very similar ways IE CYP450 enzymes, oxidations, conjugation to glucoronides etc.

As far as the subjective experiences go, I'm not really sure. I have heard that crystal meth is very harsh causing psychoses and such in addicts.
 


so is the consumption of both drugs pretty much the same as a whole? and if one dominates, is it due to sociopolitical, geographic, or economic factors or is there any other reason?
 
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