When a charge is applied to a metallic sphere, it distributes evenly across the surface due to the mobility of the charges, as explained by Gauss's Law. In contrast, charges on an insulating sphere cannot move freely, leading to potentially complex and varied charge distributions within its volume. While a uniform distribution is often assumed for simplicity, other arrangements are possible due to the restricted mobility of charges in insulators. The discussion emphasizes that the behavior of charges in metallic versus insulating spheres is fundamentally different due to the nature of charge mobility. Understanding these principles is crucial in electrostatics.