The discussion centers on understanding Python string slicing, specifically the expression s[1::-1] applied to the string s = 'hello'. It clarifies that s[::-1] reverses the string, while s[1::] slices from the second character to the end. The confusion arises with s[1::-1], which returns 'eh'. This is explained by breaking down the slicing parameters: it starts at index 1 (the letter 'e'), stops before index 0, and steps backwards, thus including 'e' and 'h' in reverse order. The thread also references Python's official documentation for further clarification on slicing behavior.