Finding the Bioavailability of a Drug using Definite Integration

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Homework Help Overview

The problem involves finding the bioavailability of a drug by calculating the area under the curve represented by the concentration function C = 15te^{-0.2t} over the interval from t = 0 to t = 3 using definite integration.

Discussion Character

  • Mathematical reasoning, Problem interpretation

Approaches and Questions Raised

  • Participants discuss the setup for integration by parts and the application of the fundamental theorem of calculus. There is a question about the correctness of the initial calculations and the evaluation of limits.

Discussion Status

Some participants have provided guidance on evaluating definite integrals and suggested performing the indefinite integral first. There is an acknowledgment of a mistake in the initial attempt, and one participant reports successfully resolving the problem after further practice.

Contextual Notes

Participants are working under the constraints of homework rules, which may limit the type of assistance provided. There is an indication that some foundational concepts may need clarification or reinforcement.

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Homework Statement


The concentration, C, in ng/ml of a drug in the blood as a function of time in hours since the drug was administered is given by

C = 15te^{-0.2t}

The area under the curve is the bioavailability, find it from t = 0 to t = 3




Homework Equations





The Attempt at a Solution



I want to find the definite integral of

C = 15te^{-0.2t}

From t = 0 to t = 3.

\int^{3}_{0}15te^{-0.2t}dt

u = 15t
du = 15 dt
v = \frac{-e^{-0.2t}}{0.2}
dv = e^{-0.2t}dt

Now, I see this as a perfectly good setup for integration by parts. Now, to set up definite integral formula.

\frac{-15te^{-0.2t}}{0.2}^{3}_{0} - \int^{3}_{0} \frac{-15e^{-0.2t}}{0.2}dt

123.4862 - 13.720 + 25

Which I know is wrong because I just graphed the integral with my calculator. So, where am I being stupid?
 
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I was taught that I could evaluate definite integrals by solving uv for the upper limit, then subtracting uv evaluated at lower limit (as if it were an integral using 1st fundamental theorem), and then subtract the integral of vdu (also using fundamental theorem).
 
Do the indefinite integral first
 
Worked it again and got it right. Need some practice.
 

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