In a system of N suspended particles diffusing through a narrow channel, neglecting hydrodynamic interactions implies that the motion of one particle does not influence its neighbors. Without these interactions, particles can only move due to external flow or other forces, as their individual movements are unaffected by the presence of other particles. The discussion highlights that hydrodynamic interactions create a flow field in the solvent that influences all particles, resulting in collective motion. If no flow field exists, particles lack the necessary forces to move, raising questions about their diffusion. The concept of settling is also mentioned as a relevant phenomenon in this context.