Calculating cylinder pressure in a four-stroke engine at specific crank angles is complex due to multiple influencing variables, including piston offset and valve timing. A single universal equation for all engines does not exist, as pressure calculations must account for unique characteristics of each engine type. The discussion highlights the challenge of adapting formulas for multiple cylinders and the need for conditional statements in spreadsheets to accurately reflect pressure changes at different angles. Participants suggest that while a working model for one cylinder can be phased for others, achieving a comprehensive solution remains elusive. Incorporating factors like inertia and friction is essential for creating a realistic pressure-volume relationship in engine simulations.