Activation analysis in fusion reactors is crucial for understanding the radioactivity of materials involved in the process. While fusion is generally considered to produce minimal high-level waste, some isotopes can be long-lived and highly radioactive, necessitating careful management of maintenance protocols. Advanced low-activation materials, such as Eurofer, have been developed to reduce activation levels in fusion devices. Simulation tools like MCNP and FISPACT can be used to model neutron spectra and track particle transmutations, aiding in the assessment of activation. Proper material selection can effectively minimize the production of long-lived activation products in fusion reactors.