The discussion explores the differences between the genes of single-celled and multi-cellular organisms, highlighting that prokaryotes have simpler DNA structures compared to eukaryotes, which possess a nucleus. It emphasizes that while the fundamental genetic mechanisms are similar, multi-cellular organisms exhibit specialized cell functions due to selective gene expression. Examples like insulin production using plasmids in single-celled organisms illustrate potential applications of single-celled genes. The conversation also touches on evolutionary aspects, noting that multi-cellular organisms evolved from single-celled ancestors, with varying degrees of organization and specialization seen in organisms like Volvox. Overall, the genetic capabilities of single-celled organisms could theoretically be utilized in multi-cellular contexts, though specific examples are limited.