Jasongreat said:
I have a brother that has been diagnosed with depression, he actually tried to take a bunch of pills and end it all a few years ago. From what I've noticed, it isn't so much if he has a positive or negative outlook on life, its more about worrying about things he has no control over which gives him his negative outlook. That is a very dangerous thing to do imo since if he has no way to change the circumstances into his favor, no way to solve the problem, he gets the feeling that why should I go on if it isn't possible to be happy. He used to allow peoples actions to take control of his life, he would sit around and just let himself get worked up over things that imo should just be forgotten about or atleast ignored. It's also very hard to talk him into just letting things go but once he does you can see his attitude change 180 degrees instantly.
The thing that scares me is when he is on his anti-depressants, since I have yet to see one advertised that suicidal thoughts isn't one of the side effects. It seems strange to me to prescribe a drug, to a segment of society, that has a side effect that is the thing they are trying to prevent but I am in no way trying to say that people should stop taking their medication, do what the doctor says...
Disclaimer: All my observations are just that, observations I have no medical training and nothing I have said should be taken as me recommending any action. I only have experience with one or two people with depression so I am in no way a credible diagnostic technician. Please follow your doctors advice.
To what extent the possible anti-depressant side effect of suicidality is real or even the exact prevalence remains in my experience a conundrum. I have treated many patients with depression and believe it
may have occurred in one or two cases. In the more unfortunate case, the young man had been seen in the ER and was started on the AD Zoloft. 9 days later he suicided. Does this mean that the AD caused the suicide? The answer depends on who you ask? The older literature postulates that there is an increased risk of suicide as people begin to respond, owing to the observation that many report increased motivational and energy levels
before any subjective improvement in mood occurs. The notion is that they may have been suicidal before but were only able to act on the thought after they started to "improve."
More recent thinking is that many of these patients may be in fact undiagnosed patients with bipolar illness instead of unipolar depression. This population is at greater risk for adverse AD related events, and some psychiatrists feel strongly that under no circumstances should they ever be given an antidepressant, as it may lead to more rapid and severe mood swings, which carries with it a much amplified risk of suicide.
The other issue to keep squarely in sight is that suicide is a risk associated with depression of whatever type--unipolar or bipolar. So it is not unreasonable to expect suicides in this population whether they have been given AD's or not. Its somewhat like the H1N1/vaccine thread--it is relatively easy to demonstrate that AD's generally save lives, and that the few cases of suicide which may or may not be the result of AD therapy, is dwarfed by the positive effects seen in the majority. Certainly great care and vigilance needs to be exercised during the first few weeks of therapy, starting with a careful discussion with the patient.
( BTW, the FDA has taken a somewhat simplistic approach IMHO that may do more harm than good in pointing out these risks in the form of black box label warnings. I hope that someone is keeping score re the number of adolescents who suicide as a result of not being treated wuth AD's because of concern over this possibility, versus those who are
caused to suicide by the meds. Unfortunately, this decision seems to be based as much on politics as medicine. The Yale study which purported to show an association in children/adolescents was considered flawed by many, and other studies which didn't show such as association were ignored).