To remove the about:blank hijacker, users should start by clearing cookies, temporary files, and emptying the recycle bin, followed by a scan with Ad-aware. If the issue persists, checking the Windows registry for suspicious entries, examining running processes for unknown applications, and searching the C:, Windows, and System32 folders for recent files can help identify the hijacker. For those seeking alternative solutions, switching to Firefox or formatting the hard drive to install Linux are suggested options. Manual removal can be tedious, so following detailed guides may be beneficial.