How Atherosclerosis cause endothelial injury?

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SUMMARY

Atherosclerosis is characterized by the accumulation of lipids, specifically cholesterol and cholesterol esters, within the intima of major blood vessels. According to "Robbins and Cotran, 8th edition," this condition results from endothelial injury rather than mere endothelial dysfunction. This injury leads to increased permeability, heightened expression of adhesion molecules, and altered endothelial function. Risk factors such as hyperlipidemia, hypertension, smoking, and diabetes mellitus contribute to endothelial dysfunction, although hypertension primarily manifests as thrombosis rather than atherosclerosis, potentially leading to myocardial infarction (MI).

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  • Understanding of atherosclerosis pathology
  • Familiarity with endothelial function and injury mechanisms
  • Knowledge of cardiovascular risk factors (hyperlipidemia, hypertension, smoking, diabetes mellitus)
  • Basic concepts of thrombosis and myocardial infarction (MI)
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  • Research the role of hyperlipidemia in endothelial injury
  • Study the mechanisms of endothelial dysfunction in cardiovascular diseases
  • Examine the relationship between hypertension and thrombosis
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Manish7
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Atherosclerosis causes accumulation of lipids (cholesterol, cholesterol esters) within the intima of major vessels."Robbins and Cotran, 8 edi." says it is due to endothelial injury rather endothelial dysfunction,which leads to increased permeability, inc. expression of adhesion molecules, altered endothelial function.
but how these risk factors (hyperlipidemia, hypertension, smoking, diabetes mellitus) causes endothelial dysfunction ?
Although Hypertension can damage endothelium, but it must manifest as a case of thrombosis rather than atherosclerosis, leading to MI.
 
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Is this a homework or coursework question?
 
This isn't any homework, I am just asking my query when going through CVS Pathology.