To determine the refractive index of a thin piece of plexiglass, one can measure the incident and refracted angles of light using the formula n = sin i/sin r. However, achieving accurate measurements can be challenging with thicker materials, as noted with a 2 cm piece yielding a value of 1.59, which is higher than the typical range of 1.49-1.51 found online. Using glycerol at 20 degrees, which has a refractive index similar to Pyrex, can provide a comparative method to verify results. It's crucial to consider the variability of refractive indices in plastics due to factors like fabrication methods and temperature. Repeating the experiment multiple times and accounting for measurement errors can help ensure reliability in the findings.