Immune Cells Involved with High Blood Pressure

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High blood pressure affects over 1 billion people globally and is linked to serious health issues such as heart attacks, strokes, kidney damage, and dementia. There is no universal treatment for hypertension, but recent research suggests that targeting immune cells may offer new control methods. A study highlighted in Science magazine demonstrates that administering the hormone angiotensin II can induce hypertension in mice, while adding the molecule 2-HOBA to their water can significantly reduce blood pressure. This finding could lead to innovative hypertension treatments for humans. However, concerns exist regarding the applicability of angiotensin II treatment, as many individuals experience hypertension due to factors other than elevated angiotensin II levels, potentially limiting the effectiveness of this approach.
BillTre
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High blood pressure can affect health in many ways.
More than 1 billion people worldwide have high blood pressure, which promotes heart attacks, strokes, kidney damage, dementia, and other ailments.
No one treatment can control it in all cases.
Treating immune cells may help control it.
Science mag news article here.
 
Biology news on Phys.org
It's fairly easy to give mice hypertension. Just regularly dose them with the hormone angiotensin II. But mixing a molecule called 2-HOBA into the animals' drinking water returns their blood pressure almost to normal, vascular biologist David Harrison of the Vanderbilt University School of Medicine in Nashville and colleagues have found. Now, that observation could open an innovative approach to treating hypertension in people.

How well does angiotensin II treatment recapitulate real cases of high blood pressure. If most people have cases of high blood pressure caused by different factors than high angiotensin II levels, the population that would respond to such a treatment could be limited.
 
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