Injecting Large volume of Nanoparticles

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The discussion centers on the interaction between nanoparticles and the human immune system (HIS), particularly regarding the potential for nanoparticles to be accepted by the body without triggering an immune response. It highlights that the immune system reacts differently to various types of nanoparticles, such as liposomes versus carbon nanotubes. The immune system has specific responses to certain patterns, such as polysaccharides found in bacteria and antigens associated with viruses, which can lead to allergic reactions or immune responses. However, if nanoparticles are designed to mimic the body's own cell surface proteins, they may evade detection and acceptance by the immune system. This concept parallels how cancer cells can evade immune responses, as they often elude detection by non-specific white blood cells, while T and B cells are less involved in the initial response. The implications of these interactions are significant for the development of nanoparticle-based therapies.
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Supposing that our body is injected with a large volume of nanoparticles carrying some specific agents to filter out our blood, I don't understand how our body HIS (human immune system) can ignore its main task to accept the agents as friends, especially after these particles succeed, where will they go ?

http://pubs.acs.org/doi/abs/10.1021/bm900266r
 
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The interaction of nanoparticles with any biological system is going to be different depending on the particle in question. A liposome isn't going to be reacted to the same way as a carbon nanotube for instance.
 
hmm well the immune system has specific inclinations and rules it follows. For example it won't ignore poly saccharides on anything, often associated with bacteria cell walls, and also unfortunately found in some vaccines causing allergical reactions. It doesn't like antigens with specific patterns found with viruses. But if you made molecules that are more similar to the body's own cell surface proteins, it might work.

This is how cancer evades the immune system. Even when the immune system go after cancer cells it's the non specific WBCs and not your T and B cells that do the job.
 
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