Intracellular Mechanism of IGF-1

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IGF-1 has demonstrated potential in enhancing nerve cell regeneration, but the specific mechanisms behind this effect remain largely unclear. Current research primarily indicates a neuroprotective role of IGF-1 without delving deeply into the underlying processes. A search on PubMed for "IGF-1 and neurons" yields numerous studies, with some suggesting involvement of the PI3 kinase pathway, yet comprehensive insights into the mechanisms are still lacking. Textbooks may not provide detailed information on this topic, reflecting the ongoing nature of research in this area.
nautica
IGF-1 has been shown to increase regeneration of nerve cells. I have seen the studies, but am unable to find the actual mechanisms. Does anybody have any information on this or know where I could find it.

I have look through my cell and molecular biology book, but can not seem to find it.

thanks
nautica
 
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I doubt you'll find anything in a textbook on it. I don't think the mechanism is fully understood yet. Most of what I find on the topic seems to still be on a pretty basic level: add IGF-1 and see an effect on neuroprotection. If you do a pubmed search on "IGF-1 and neurons" you'll get a long list of results. I only skimmed a few pages in and saw a few titles suggesting the PI3 kinase pathway may be involved, but nothing more than that.
 
Yup, that's what I was afraid of.

Thanks for your thoughts.
Nautica
 

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