Isaac Newton developed calculus through his exploration of motion and change, focusing on concepts like limits and infinitesimals. The antiderivative is essential for finding the area under a curve, which is a fundamental application of calculus. The expression F(b) - F(a) represents the net change in the function between two points, crucial for understanding accumulation. While the discussion touches on these foundational concepts, it emphasizes that the historical development by Newton and Leibniz is distinct from the practical applications taught in calculus courses. Understanding these principles requires a deeper dive into calculus texts and their explanations.