Macroscopic properties of matter emerge when considering a sufficient number of atoms, typically around 1,000 molecules, where statistical effects become significant. The discussion highlights the transition from quantum to classical behavior, often associated with the Planck mass, which is about 10^-8 kg. Finite size confinement impacts materials at scales of 1-1,000 nm, complicating the definition of macroscopic properties. The conversation also touches on the nature of matter at extreme conditions, such as black holes, and the merging of particles like protons and quarks. Ultimately, the question of when macroscopic properties appear lacks a precise answer, as it is explored in the field of mesoscopic physics, which examines the continuum from atomic to bulk materials.