To expand the expression (2X+Y)^5 efficiently, the Binomial Theorem, also known as Newton's Expansion, is recommended over successive multiplication. The theorem states that (a+b)^n can be expressed as a series involving coefficients derived from combinations, specifically C(m out of n), where 'a' and 'b' are the terms being expanded and 'n' is the exponent. The coefficients can be found using Pascal's Triangle, which illustrates the pattern of coefficients for each power. For (2X+Y)^5, the coefficients from Pascal's Triangle are 1, 5, 10, 10, 5, and 1. Substituting 2X for 'a' and Y for 'b' in the expansion formula yields the complete expansion. This method is significantly faster and more systematic than manual multiplication.