Meaning of a reaction being "too slow to be biologically significant"?

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SUMMARY

The phrase "too slow to be biologically significant" refers to reactions that occur at a probability so low that their impact on biological systems is negligible. In the context of the auto-oxidation of nitric oxide (NO) to form nitrogen dioxide (NO2), this indicates that while the reaction does occur, its rate is insufficient to affect biological processes meaningfully. The National Research Council's guidelines specify a 24-hour exposure limit of 0.04 ppm for NO2, emphasizing the importance of dosage in assessing toxicity.

PREREQUISITES
  • Understanding of chemical kinetics and reaction rates
  • Familiarity with the auto-oxidation process of nitric oxide (NO)
  • Knowledge of biological significance in toxicology
  • Awareness of exposure limits and guidelines for nitrogen dioxide (NO2)
NEXT STEPS
  • Research the kinetics of the auto-oxidation of nitric oxide (NO)
  • Study the biological effects of nitrogen dioxide (NO2) exposure
  • Examine the principles of dose-response relationships in toxicology
  • Explore the guidelines set by the National Research Council regarding air quality standards
USEFUL FOR

This discussion is beneficial for toxicologists, environmental scientists, and researchers studying the effects of nitrogen oxides on health and the environment.

asimov42
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I'm wondering if there's a clear definition of the phrase "too slow to be biologically significant"? (in this case the reaction of the auto-oxidation of $$NO$$ to form $$NO_2$$) Does this simply mean the reaction occurs with a very low probability? Presumably the reaction does still occur - I'm wondering if there's a clear technical definition.

Thanks.
 
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Per CDC guidelines, the National Research Council's Short-term Public Emergency Guidance Level for a 24-hour exposure to NO2 is 0.04ppm (for inhalation).
The point is: Only the dose makes the poison (at least for NO2). And a thank you to 16th Century Paracelsus.
 

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