I'm wondering if anyone is aware of any computational/theoretical work on solving the problem of describing the motion of a biological macromolecule in a cellular microdomain? This would have to mean setting up and solving a stochastic partial differential equation with boundary conditions defined by the geometry/permeability of the microdomain in question.(adsbygoogle = window.adsbygoogle || []).push({});

I've seen various papers on anisotropic diffusion but most are considering the case where there is no boundary. As an example, this paper comes to mind: Brownian Motion of an Ellipsoid (2006) Science Han et al.

http://www.sciencemag.org/cgi/content/abstract/314/5799/626

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# Models of the diffusion of biological macromolecules

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