These are so-called directional derivatives.
So, let's say we are given a function [itex]f:\mathbb{R}^3\rightarrow \mathbb{R}[/itex] and a unit vector [itex]\mathbf{v}=(v_1,v_2,v_3)[/itex]. The the directional derivative of f in v is given by
[tex]D_\mathbb{v} f = v_1\frac{\partial f}{\partial x}+v_2\frac{\partial f}{\partial y}+v_2\frac{\partial f}{\partial z}[/tex]
First of all, note that if [itex]\mathbb{v}=(1,0,0)[/itex], then we just obtain the partial derivative with respect to x. So this is clearly the case where you differentiate with respect to the x-axis.
As an example, given [itex]f(x,y,z)=x^5yz^4+\log(x)\sin(yz)[/itex]. We wish to find the partial derivative with respect to the line x=y=-z. A unit vector on this line is given by [itex]\mathbb{v}=(\frac{1}{\sqrt{3}},\frac{1}{\sqrt{3}},-\frac{1}{\sqrt{3}})[/itex]. (of course, [itex]-\mathbb{v}[/itex] is another unit vector but this vector will give us the same directional derivative up to a sign). So, we have
[tex]\frac{\partial f}{\partial x}=5x^4yz^4 + \frac{\sin(yz)}{x}[/tex]
[tex]\frac{\partial f}{\partial y}=x^5z^4 + z\log(x)\cos(yz)[/tex]
[tex]\frac{\partial f}{\partial z}= 4x^5yz^3 + y\log(x)\cos(yz)[/tex]
So
[tex]D_\mathbb{v} f = \frac{1}{\sqrt{3}}(5x^4yz^4 + \frac{\sin(yz)}{x})+\frac{1}{\sqrt{3}}(x^5z^4 + z\log(x)\cos(yz)) -\frac{1}{\sqrt{3}}(4x^5yz^3 + y\log(x)\cos(yz))[/tex]