Picture of H1N1 and what are those appendages used for?

  • Thread starter squidsoft
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In summary, the viral proteins HA and NA sit in the outer membrane of the virus and are responsible for gaining entry into the cell membrane, while M2 is an ion channel that allows the virus to sense the pH of its surroundings. Once the virus enters the cell, it is in an endocytotic vesicle and M2 conveys this acidification to protein inside the virion, triggering the mechanisms in the virus that cause the release of its genetic material into the cell.
  • #1
squidsoft
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I think it's quite an accomplishment to obtain a picture (from LiveScience) of a new viral infection. I can tell the virus has a set of "arms" attached all around it's outer coat. I assume this is for gaining entry into the cell membrane. Not sure though. Can someone explain what the purpose of these arms are for?
 

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These "arms" are actually proteins that sit in the outer membrane of the virus. There are three viral proteins in the outer membrane of influenza: M2, HA, and NA; however, M2 does not protrude significantly outside the membrane, so the proteins that you are see in the electron micrograph are HA and NA.

HA, short for hemagglutinin, is a protein that allows influenza to bind to mammalian cells in order to infect them. It is also involved in fusing the viral membrane with the cell's membrane, allowing the virus's genome to enter the cell and begin replicating new viruses.

NA, short for neuraminidase, is an enzyme involved in clipping sugar molecules off of the surface of cells. Since these surface molecules tether budding virions onto the host cells, NA is essential for the release of new virions into the body so that they can infect other cells. Notably, the drug tamiflu targets NA.

For completeness, I'll note that M2 is an ion channel that allows the virus to sense the pH of its surroundings. This is important because once the virus enters the cell, it is in an endocytotic vesicle. Usually the cell will try to digest material that it takes up through endocytosis, and the first step in this process is acidifying the interior of the vesicle. M2 conveys this acidification to protein inside the virion, triggering the mechanisms in the virus that cause the release of its genetic material into the cell.
 
  • #3
You have the right idea - there are co-receptor sites on cell membranes those "bind" to.
Here is a not-too-technical explanation for HIV.

http://en.wikipedia.org/wiki/CCR5
 

1. What is H1N1?

H1N1 is a subtype of the influenza A virus, also known as the "swine flu". It caused a global pandemic in 2009.

2. What does the picture of H1N1 show?

The picture of H1N1 shows the structure of the virus, including its outer membrane, inner core, and various appendages.

3. What are the appendages on the surface of H1N1?

The appendages on the surface of H1N1 are called hemagglutinin (HA) and neuraminidase (NA). These proteins are important for the virus to bind to and enter host cells.

4. What is the function of HA and NA on H1N1?

HA helps the virus attach to host cells and enter them, while NA helps the virus release itself from infected cells to spread to other cells in the body.

5. How does understanding the structure of H1N1 help in developing treatments?

Understanding the structure of H1N1 allows scientists to identify key targets on the virus that can be targeted by antiviral medications or vaccines. It also helps in predicting how the virus may mutate in the future and how to combat those changes.

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