How Can I Grow Crystals of My Platinum Complexes?

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The discussion centers on the challenges of growing crystals from platinum(II) complexes, specifically derivatives of cisplatin with bulky hydrophobic amine ligands. The primary issue is the solubility of these complexes, which are poorly soluble in water but soluble in DMF, a solvent that has not yielded successful crystallization. Acetonitrile was also attempted without success. Participants suggest exploring a wider range of solvents beyond DMF and acetonitrile, including DMSO, methanol, hexane, acetone, and dichloromethane, as well as more complex solvents like toluene and pyridine. The conversation emphasizes the importance of experimenting with various solvents and methods for recrystallization to achieve successful crystal growth. Additionally, references to recent methods for crystallizing similar complexes are provided for further exploration.
KarolinaPL
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Hi! i prepare different platinum(II) complexes, derivatves of cisplatin, where one or two ammine ligands are substituted by bulky hydrophobc amine... i would like to grow crystals, but i have a problem with it... the solvent... they are usually poor soluble in water, good soluble in e.g. DMF... but DMF didnt work for crystals. In similar case, they used acetonitrile, i tried as well, it didnt work...
 
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KarolinaPL said:
Hi! i prepare different platinum(II) complexes, derivatves of cisplatin, where one or two ammine ligands are substituted by bulky hydrophobc amine... i would like to grow crystals, but i have a problem with it... the solvent... they are usually poor soluble in water, good soluble in e.g. DMF... but DMF didnt work for crystals. In similar case, they used acetonitrile, i tried as well, it didnt work...

How, specifically, did those soluble solvents not work? Did the molecule decompose? Did it become some amorphous gel? Are DMF and acetonitrile the only solvent you have tried? Typically, searching for solvents for recrystallization require you to try out all the available solvents. DMSO, methanol, hexane, acetone, dimethylether, dichloromethane, chloroform, etc. There are lots of other solvents out there. If these relatively safe solvents don't work, try toluene, benzene, pyridine, etc.I can also suggest you several recrystallization methods you can try, but I would like to know above information first.
 

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