To achieve a desired voltage gain of 50 in a common emitter (CE) transistor amplifier, it's recommended to use two stages, each providing a gain of approximately 7. The gain formula is given by Gain = (Rc // Rl) / (Re + r'e), where r'e is approximately 25Ω at 1mA bias current. For an output impedance of 2K, Rc should be set to 2K, and Re can be calculated based on the desired gain and load conditions. The discussion emphasizes the importance of approximations in transistor design due to variability in components and suggests using resources like Malvino's electronics principles for further learning.