Primary Amebic Meningoencephalitis

  • Thread starter Thread starter Ken Ramos
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The discussion centers on Primary Amebic Meningoencephalitis (PAM), a severe infection caused by the thermophilic amoeba Naegleria fowleri, typically resulting in nearly 100% mortality. Participants express concern about the potential increase in PAM cases due to global warming, as the amoeba thrives in warm freshwater environments, including poorly treated swimming pools. There is interest in the number of misdiagnosed cases, as PAM can be mistaken for bacterial infections, often only identified post-mortem. The conversation invites insights and additional research on PAM, its mortality rates, and the implications of environmental changes on its prevalence.
Ken Ramos
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Anyone here familiar with this topic? If so, have you done any research relating to the infection and the mortality rates resulting from it. I am curious as to the possibility of this infection becoming more pronounced with the advent of global warming, since the cause of it is a small thermphilic amoeba. PAM (Primary Amebic Meningoencephalitis) is usually 100% fatal. However there have been four or maybe five reported cases of the host having survived this often fatal infection. I am also curious as to how many cases there have been which were misdiagnosed due to the infection appearing as a bacterial infection rather than amebic, which most often occurs and is not realized until after autopsy of the infected and then deceased host.
The cause of the infection is the introduction of the amoeba Naegleria fowleri into the nasal cavity during swimming or diving into warm fresh natural waters, where it then travels via the CNS (Central Nervous System) to the brain. Of course there it begins to propogate and cause sever bleeding, destruction of brain cell tissues and of course swelling leading to the death of the host. The amoeba can also thrive in most any warm body of freshwater including poorly treated swimming pools.
In any case I would enjoy hearing what others may have to say on this infection and what light they may have to shed on what I have not or may have already researched. Thanks:smile:
 
Biology news on Phys.org
Primary Amebic Meningoencephalitis -- North Carolina, 1991
http://www.cdc.gov/mmwr/preview/mmwrhtml/00016999.htm

Primary Amebic Meningoencephalitis --- Georgia, 2002
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5240a4.htm

Emerging Infectious Diseases
Fatal Naegleria fowleri Meningoencephalitis, Italy
http://www.cdc.gov/ncidod/EID/vol10no10/04-0273.htm

CDC also does - Surveillance for Waterborne-Disease Outbreaks
http://www.cdc.gov/search.do?action=search&queryText=Primary+Amebic+Meningoencephalitis+&x=7&y=8
 
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