The reason that the mathematics of quantum mechanics isn't applied at the macroscopic level, is because the mathematics of it is extrodinarily complex. That mathematics is so complex, that quantum mechanics can't even be used (perfectly) for atoms above hydrogen. In other words, if you want to get to the moon, you aren't going to solve schrodinger's equation to do so, you are going to use Newton's laws.
But, in principle, if quantum mechanics were the theory of everything, then in principle it could be used to get you to the moon, except for the fact that someone using Newtons laws would have a far shorter computer program, for onboard computers.
All this having been said, quantum mechanics is not the last word on physics, because there are serious problems with the interpretation of the mathematics being used. Consider the quantum measurement problem, consider Schrodinger's cat, etc.