Medical Question about designing therapies for HIV

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The discussion centers on the potential for creating a virus that targets and kills HIV-infected cells while replicating at a faster exponential rate than HIV itself. The example used illustrates HIV's replication in base 2, where one infected cell leads to two new infections, and so forth. The inquiry raises concerns about the implications of a faster-replicating virus, questioning whether it could pose a greater threat to the body. It highlights the complexity of virology and the limited understanding of many viruses. Additionally, the conversation notes that there may already be natural candidates for such a virus, but challenges similar to those faced in using bacteriophages could arise, particularly regarding the immune system's ability to combat the new pathogen.
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As far as I know, HIV replicates itself at an exponential rate in a base b. For simplicity, let b = 2.

For example, if one cell is infected, then HIV makes one copy of itself (since b = 2). And the cell dies to infect two new cells. These two new cells die to infect four new cells and so on...

My question is whether it is possible to create a virus that immediately kills only HIV-infected cell but replicates at an exponential rate higher than that of HIV's.

If HIV replicates itself in base 2 but the viral medicine replicates itself in base 6, then it's apparent that the viral medicine spreads much faster than HIV.
 
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r731 said:
My question is whether it is possible to create a virus that immediately kills only HIV-infected cell but replicates at an exponential rate higher than that of HIV's.

Wouldn't this new virus be even worse if it's infecting your body's cells to replicate at a faster rate than HIV?
 
This is in fact a relatively new area of interest in virology, we still have such limited information about most viruses and they inhabit a surprisingly complex world. I don't know about creating one, it appears there may already be some potential candidates in nature. I suspect that the main problems will be similar to the ones seen in attempts to use bacteriophages, our own immune system might help protect the pathogen. You might find this interesting.
https://varuncnmicro.blogspot.com/2012/11/a-rival-for-hiv.html
 
I've been reading a bunch of articles in this month's Scientific American on Alzheimer's and ran across this article in a web feed that I subscribe to. The SA articles that I've read so far have touched on issues with the blood-brain barrier but this appears to be a novel approach to the problem - fix the exit ramp and the brain clears out the plaques. https://www.sciencealert.com/new-alzheimers-treatment-clears-plaques-from-brains-of-mice-within-hours The original paper: Rapid amyloid-β...
https://www.discovermagazine.com/the-deadliest-spider-in-the-world-ends-lives-in-hours-but-its-venom-may-inspire-medical-miracles-48107 https://en.wikipedia.org/wiki/Versutoxin#Mechanism_behind_Neurotoxic_Properties https://www.sciencedirect.com/science/article/abs/pii/S0028390817301557 (subscription or purchase requred) The structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel...

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