Question about designing therapies for HIV

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SUMMARY

This discussion centers on the potential development of a virus that targets and kills HIV-infected cells while replicating at a higher exponential rate than HIV itself. The concept is illustrated using a base replication model, where HIV replicates at base 2 and the proposed viral medicine at base 6. The conversation highlights the complexities of virology and the challenges posed by the human immune system in creating such a virus. Additionally, it references existing natural candidates that may exhibit similar properties.

PREREQUISITES
  • Understanding of exponential replication rates in virology
  • Familiarity with HIV replication mechanisms
  • Knowledge of viral vector design
  • Basic concepts of the human immune response to pathogens
NEXT STEPS
  • Research viral vector design techniques for targeting specific cells
  • Explore the role of bacteriophages in viral therapy
  • Investigate existing natural viruses that may target HIV
  • Study the immune system's response to engineered viruses
USEFUL FOR

Virologists, researchers in infectious diseases, and professionals involved in developing antiviral therapies will benefit from this discussion.

r731
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As far as I know, HIV replicates itself at an exponential rate in a base b. For simplicity, let b = 2.

For example, if one cell is infected, then HIV makes one copy of itself (since b = 2). And the cell dies to infect two new cells. These two new cells die to infect four new cells and so on...

My question is whether it is possible to create a virus that immediately kills only HIV-infected cell but replicates at an exponential rate higher than that of HIV's.

If HIV replicates itself in base 2 but the viral medicine replicates itself in base 6, then it's apparent that the viral medicine spreads much faster than HIV.
 
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r731 said:
My question is whether it is possible to create a virus that immediately kills only HIV-infected cell but replicates at an exponential rate higher than that of HIV's.

Wouldn't this new virus be even worse if it's infecting your body's cells to replicate at a faster rate than HIV?
 
This is in fact a relatively new area of interest in virology, we still have such limited information about most viruses and they inhabit a surprisingly complex world. I don't know about creating one, it appears there may already be some potential candidates in nature. I suspect that the main problems will be similar to the ones seen in attempts to use bacteriophages, our own immune system might help protect the pathogen. You might find this interesting.
https://varuncnmicro.blogspot.com/2012/11/a-rival-for-hiv.html
 

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