Big G, or the gravitational constant, is a crucial constant of proportionality in Newton's law of universal gravitation, which relates the gravitational force between two masses to their masses and the distance between them. It has units of N*m²/kg², balancing the equation F = G*m1*m2/r². The discussion highlights the difference in how force is defined in Newton's second law (F = ma) compared to gravitational force, noting that G is not needed in the latter because it is inherently included in the definition of gravitational acceleration. The conversation also touches on the implications of unit systems on the value of G, suggesting that its smallness is a result of the chosen units rather than a fundamental property. Overall, G serves as a bridge between mass and gravitational force, illustrating the relationship between these quantities in gravitational interactions.