To determine how many times you need to roll six dice to see all six different numbers, the average is calculated to be 64.8 rolls. This figure is derived from the probability of rolling all six values, which is 6! divided by 66 possible outcomes. The calculation simplifies to a probability of 5/324 for achieving all six numbers in one roll. Consequently, the average interval for such outcomes follows a Poisson distribution, leading to the result of 64.8 rolls. The discussion emphasizes the mathematical reasoning behind this probability puzzle.