Salvia Divinorum for treatment of addiction

  • Thread starter cronxeh
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  • #1
cronxeh
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According to this paper http://www.sagewisdom.org/zhangetal.pdf Salvinorin A (active compound in Salvia Divinorum) lowers dopamine levels significantly right after injection.

And according to "Dopamine hypothesis of schizophrenia" ( http://en.wikipedia.org/wiki/Dopamine_hypothesis_of_psychosis ):

Disruption to the dopamine system has also been strongly linked to psychosis and schizophrenia. Dopamine neurons in the mesolimbic pathway are particularly associated with these conditions. This is partly due to the discovery of a class of drugs called the phenothiazines (which block D2 dopamine receptors) that can reduce psychotic symptoms, and partly due to the finding that drugs such as amphetamine and cocaine (which are known to greatly increase dopamine levels) can cause psychosis. Because of this, most modern antipsychotic medication is designed to block dopamine function to varying degrees. Blocking the D2 dopamine receptor is known to cause relapse in patients that have achieved remission from depression, and such blocking also counteracts the effectiveness of SSRI medication.
Could Salvia divinorum be used for treatment of psychosis in amphetamine/cocaine addicts and schizophrenia?
 

Answers and Replies

  • #2
DocToxyn
Science Advisor
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Direct use of Salvinorin A may not be the best solution to drug-induced psychoses or schizophrenia. Since the agent itself a hallucinogen, you may simply be trading one symptom for another. Perhaps by studying the specific pharmacological/receptor characteristics of the drug we could more readily create a more useful agent with less deleterious side-effects.
 

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