Certain isotopic separation techniques, particularly for U-235, U-233, and Li-6, are highly sensitive due to their potential use in nuclear weapons, leading to strict regulation by agencies like the NNSA and NRC. Other isotopes, such as Deuterium, Boron, Oxygen, and Silicon, do not face similar regulatory scrutiny as they lack significant national security concerns, focusing instead on economic factors. The efficiency of enrichment processes directly influences regulatory control, with advanced techniques like Laser Isotopic Separation (AVLIS and SILEX) being classified and requiring stringent security measures. While Boron-10 separation could raise concerns due to Boron-11's potential as fusion fuel, the sensitivity of regulation ultimately depends on the specific technology used. Overall, the classification and control of isotopic separation technologies are crucial for maintaining national and global security.