Understanding calculus is essential for grasping the concepts in the Feynman Lectures, especially for students who may struggle without a foundational knowledge. It's recommended to learn some basic calculus, such as derivatives and integrals, to enhance comprehension of the physics presented. While it's beneficial to grasp the general ideas of the lectures, having a working knowledge of calculus will aid in interpreting and solving physics problems. Engaging with the material can provide a better understanding, even if detailed calculus knowledge is not yet acquired. Balancing the learning of calculus with the reading of the lectures is advised for a more comprehensive educational experience.