To find the equation of a line perpendicular to y = -1/4x - 12 that passes through the point (3, -4), the slope of the new line must be the negative reciprocal of -1/4, which is 4. Using the point-slope form of a line, y - y1 = m(x - x1), where m is the slope and (x1, y1) is the point (3, -4), the equation can be derived. The calculation involves substituting the point into the equation to solve for the y-intercept, b. Ultimately, the resulting equation will represent the desired perpendicular line. Understanding the relationship between the slopes of perpendicular lines is key to solving this problem.