what I'm saying is, essentially when physicists (as well as the rest of us) measure any physical quantity, they measure it against some other like-dimensioned quantity. in that, they are measuring a dimensionless number similar to when we commonly measure a length by use of a ruler and counting tick marks on it. so if c \ somehow changes but all dimensionless constants remain the same, and all we can ultimately measure are dimensionless values, then we can't tell if c \ changed and that "change" is meaningless in our existence. a better way to put it is that if \alpha = \frac{e^2}{\hbar c 4 \pi \epsilon_0} \ changes (which is something we can measure), we do not know if that change in \alpha \ was due to a change in c \ or if it was due to something else. what it is that changed depends on how we define our units, and as Duff puts it: "[Nature] doesn't give a fig which units are chosen."
this is sort of a tautology but i do not consider it to be particularly bad to make this point by use of tautology. in my opinion, the weak anthropic principle is a tautology. saying it tells us nothing new, really, but it does help me think about a persistent question often posed by the intelligent design folks.
i don't know if the ideas of length, time, mass, etc. are merely man-made, but clearly the definitions of the meter, second, and kilogram are. before the meter was redefined to its present form, we had a definition of meter and second that did not depend on the speed of light. we made many different measurements of it and got different answers, mostly due to experimental error. in the sixties, when people became more and more confident about their measurement the meter was redefined because a good atomic clock was easier to reproduce than platinum bars with precise scratch marks on them. but now think about this, with this redefinition, the meter is the distance light travels in 1/299792458th second. that defines the speed of light to be 299792458 m/s . if c \ changes, it is still 299792458 m/s. you can think of it similarly if you measured everything in Planck units no matter what c \ is, it is still 1 in Planck units (and same for G \ and \hbar \).
now, the fact is that a meter is about the size of us humans (small wonder). i don't know why an atom's size is approximately 10^{25} l_P \, but it is, or why biological cells are about 10^{5} \ bigger than an atom, but they are, or why we are about 10^{5} \ times bigger than the cells, but we are and if any of those dimensionless ratios changed, life would be different. but if none of those ratios changed, nor any other ratio of like dimensioned physical quantity, we would still be about as big as 10^{35} l_P \, our clocks would tick about once every 10^{44} t_P \, and, by definition, we would always perceive the speed of light to be c = \frac{1 l_P}{1 t_P} \ which is the same as how we do now, no matter how some black hole or "god-like" manipulator changes it.
now if some dimensionless value like \alpha \ changed, that's different. we would perceive the difference. but to attribute that change to a change in c \, that case is not defensible. you could argue that the change in \alpha \ is due to a change in the speed of light, and i could argue it's a change in Planck's constant or the elementary charge and there is no way to support one over the other. and it shouldn't matter. my paraphrase is "Nature doesn't give a rat's ass that you choose a system of units that define some set of constants nor that i choose a different set of units that defines a different set of constants."